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Wei Chen et al. Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling.

doi: 10.1186/s13046-024-03168-8
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Chunge Zhong et al. CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer.

doi: 10.1038/s41467-024-49673-4
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Yizhou Li et al. Functional profiling of serine, threonine and tyrosine sites.

doi: 10.1038/s41589-024-01731-0
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Jiacheng Deng et al. Regulated transformation system (RTS): sddi-mediated programmable shut-off and mode switching of base editors.

doi: 10.1093/nar/gkag162
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Wu, X., Yuan, H., Wu, Q. et al. Threonine fuels glioblastoma through YRDC-mediated codon-biased translational reprogramming. Nat Cancer 5, 1024–1044 (2024).

doi: 10.1038/s43018-024-00748-7
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Li L, Feng C, Zhang W, Qi L, Liu B, Wang H, Li C, Li Z, Tu C, Zhou W. Mitigation of Cisplatin-Induced Nephrotoxicity and Augmentation of Anticancer Potency via Tea Polyphenol Nanoparticles' Codelivery of siRNA from CRISPR/Cas9 Screened Targets. ACS Appl Mater Interfaces. 2024 Nov 6;16(44):59721-59737.

doi: 10.1021/acsami.4c10171
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Gao GB, Chen L, Pan JF, Lei T, Cai X, Hao Z, Wang Q, Shan G, Li J. LncRNA RGMB-AS1 inhibits HMOX1 ubiquitination and NAA10 activation to induce ferroptosis in non-small cell lung cancer. Cancer Lett. 2024.

doi: 10.1016/j.canlet.2024.216826
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Xiaolong Cheng et al. Modeling CRISPR-Cas13d on-target and off-target effects using machine learning approaches.

doi: 10.1038/s41467-023-36316-3
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Lei HQ, Wang ZF, Jiang DG, et al. CRISPR screening identififies CDK12 as a conservative vulnerability of prostate cancer. Cell Death Dis. 2021.

doi: 10.1038/s41419-021-04027-6
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Xu P, Liu ZH, Liu Y, et al. Genome-wide interrogation of gene functions through base editor screens empowered by barcoded sgRNAs. Nature Biotechnology. 2021.

doi: 10.1038/s41587-021-00944-1
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Zhu SY, Liu Y, Zhou Z, et al. Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry. 2021.

doi: 10.1007/s11427-021-1990-5
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Liu XJ, Liu TT, Shang YF, et al. ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells. Cell Reaserch. 2020.

doi: 10.1038/s41422-020-0328-3